The healing effect of D. M. on fracture, wound, extraction socket, oral soft tissue been studied. In recent studies, Glickman researched about the hew bone formation in periodontal disease under D. M. streptozotocin, used as D. M. inducer in
experimental animals, has been used as broad spectrum antibiotics, anticancer drugs and carcinogen since 1960 years. Interestingly nowadays strepoozotocin in use to make the experimental diabetic animal model.
Following microscopic examination of healing of extraction sockets in no-diabetic rats and that of streptozotocin induced diabetic rats.
@ES The results were as follows:
@EN 1. Trabecular formation consisting of osteoid could be seen in extraction sockets in control group(nondiabetic rats) after 1 week.
More chronic inflammation and less granulation tissue were seen in experimental group than control group after 1 week.
Trabecular pattern was seen after 4 weeks in experimental group. Trabecular pattern in control group was seen from 2 weeks specimen and became hardened after 4 weeks.
Experimental group showed delayed revascullarization, poor granulation tissue formation and incomplete trabecular formation. So it is suggested that D. M. has much more adverse effect on the healing process of the extraction sockets.
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